Influence of Cardiovascular Risk Factors and Metabolic Syndrome on Epicardial Adipose Tissue Thickness in Rural Spanish Children and Adolescents

Nutrients. 2024 Sep 30;16(19):3321. doi: 10.3390/nu16193321.

Abstract

The presence of visceral adipose tissue implies a higher risk of cardiovascular diseases than subcutaneous adiposity, the most dangerous heart fat. Epicardial adipose tissue (EAT) could have great potential as a detection indicator of cardiovascular diseases, although it has seldom been studied in Spanish children.

Objective: The objective of the current research was to describe the values of EAT in a Spanish pediatric population and to investigate the associations between EAT and anthropometric measures, blood pressure, lipid and glucose profiles, and metabolic syndrome.

Method: An analytical cross-sectional study of elementary and high school students (aged 6 to 17) measured anthropometrics, blood pressure, lipid and glycemic profiles, and echocardiographic fat thickness. The analysis was based on regression and discriminant analysis.

Results: The results of this study (N = 227) showed that the body mass index (BMI) was 20.29 ± 4.54, with an overweight set of 49.77%, and the percentage for metabolic syndrome was 5.3%. EAT was linked to being male, BMI percentile, waist circumference, waist-to-height ratio (p < 0.001), hypertension, higher low-density lipoprotein (LDL) levels, and metabolic syndrome (p < 0.05).

Conclusions: This paper argues that in children with higher elevated EAT thickness values, this correlates with cardiovascular risk factors including high blood pressure, elevated LDL levels, and metabolic syndrome.

Keywords: adolescents; cardiovascular risk factors; children; epicardial fat; metabolic syndrome.

MeSH terms

  • Adipose Tissue*
  • Adiposity
  • Adolescent
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases* / epidemiology
  • Cardiovascular Diseases* / etiology
  • Child
  • Cross-Sectional Studies
  • Epicardial Adipose Tissue
  • Female
  • Heart Disease Risk Factors*
  • Humans
  • Intra-Abdominal Fat / diagnostic imaging
  • Male
  • Metabolic Syndrome* / epidemiology
  • Pericardium* / diagnostic imaging
  • Risk Factors
  • Rural Population / statistics & numerical data
  • Spain / epidemiology

Grants and funding

This research received no external funding.