Importance: Artificial intelligence (AI) has made invaluable contributions to the technologic advancements across many fields. It is transforming health care and may have a role in improving patient outcomes in facial plastic and reconstructive surgery (FPRS). Observations: In recent years, new automated approaches to simulating and analyzing outcomes using AI have emerged. Advances in rhinoplasty, facelifts, orthognathic surgery, facial reanimation, and preoperative consultation are currently being developed in FPRS. Conclusions and Relevance: Applications of AI have been applied to assist facial plastic surgeons in the preoperative stage, intraoperative planning process, and objective assessment of postoperative outcomes. The application of AI provides avenues to improve postoperative outcomes, while also optimizing patient care.