Novel method for assessing sinusoidal obstruction syndrome using four-dimensional computed tomography

Saori Shimoyama-Ibuki; Satoshi Iyama; Yoshiya Ohashi; Kento Ono; Yusuke Sugama; Chisa Fujita; Akari Goto; Hiroto Horiguchi; Akihito Fujimi; Takeo Tanaka; Kohichi Takada; Koh-Ichi Sakata; Masayoshi Kobune

doi:10.1002/jha2.990

Novel method for assessing sinusoidal obstruction syndrome using four-dimensional computed tomography

EJHaem. 2024 Jul 31;5(5):1038-1042. doi: 10.1002/jha2.990. eCollection 2024 Oct.

Authors

Affiliations

¹ Department of Hematology Sapporo Medical University School of Medicine Sapporo Japan.
² Division of Clinical Laboratory Sapporo Medical University Hospital Sapporo Japan.
³ Division of Radiology and Nuclear Medicine Sapporo Medical University Hospital Sapporo Japan.
⁴ Department of Hematology Sapporo Kiyota hospital Sapporo Japan.
⁵ Department of Medical Oncology Sapporo Medical University School of Medicine Sapporo Japan.
⁶ Department of Radiology Sapporo Medical University School of Medicine Sapporo Japan.

Abstract

Introduction: To diagnose sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), transabdominal ultrasonography is usually used to detect hemodynamic changes, but we tried to detect the changes using four-dimensional computed tomography (4D-CT). A 42-year-old Japanese woman was diagnosed with late-onset SOS/VOD with transabdominal ultrasonography and was also assessed using 4D-CT. Method We analyzed the portal vein (PV) contrast effect every 1.5 seconds and plotted the values of the contrast effect. With this graph, we analyzed three hemodynamic parameters.

Result: We found that these parameters correlated with the patient's status and indicated stasis due to sinusoid constriction.

Conclusion: 4D-CT may become a helpful tool to diagnose and follow up with SOS/VOD.

Keywords: four‐dimensional computed tomography; hematopoietic stem cell transplantation; sinusoidal obstruction syndrome; veno‐occlusive disease.