Stalling out chromatin machinery-Oncohistone mutation disrupts heterochromatin memory

Sara R Wasserman; Nathaniel A Hathaway

doi:10.1016/j.molcel.2024.09.028

Stalling out chromatin machinery-Oncohistone mutation disrupts heterochromatin memory

Mol Cell. 2024 Oct 17;84(20):3861-3862. doi: 10.1016/j.molcel.2024.09.028.

Authors

Sara R Wasserman¹, Nathaniel A Hathaway²

Affiliations

¹ Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: hathaway@unc.edu.

PMID: 39423792
DOI: 10.1016/j.molcel.2024.09.028

Abstract

In this issue, Sinha et al.¹ use cellular chromatin reporter assays along with CRISPR gene editing to reveal that the histone H3.3K36M oncohistone mutation disrupts epigenetic memory and stability of H3K9me3 domains by blocking transitions into a stably repressed state.

MeSH terms

Chromatin / genetics
Chromatin / metabolism
Epigenesis, Genetic*
Heterochromatin* / genetics
Heterochromatin* / metabolism
Histones* / genetics
Histones* / metabolism
Humans
Mutation*

Substances

Heterochromatin
Histones
Chromatin