When fibrosis intersect: Association and risk factors between Peyronie's and Dupuytren's diseases

Valentine Lethuillier; Benoit Peyronnet; Claire Richard; Charles-Karim Bensalah; Romain Mathieu; François Robin; Antoine Faix; Jean-Luc Roux; Lucas Freton

doi:10.1016/j.fjurol.2024.102759

When fibrosis intersect: Association and risk factors between Peyronie's and Dupuytren's diseases

Fr J Urol. 2024 Oct 18:102759. doi: 10.1016/j.fjurol.2024.102759. Online ahead of print.

Authors

Valentine Lethuillier¹, Benoit Peyronnet¹, Claire Richard¹, Charles-Karim Bensalah¹, Romain Mathieu¹, François Robin², Antoine Faix³, Jean-Luc Roux⁴, Lucas Freton¹

Affiliations

¹ Département d'urologie, CHU de Rennes, Rennes, France.
² Département de rhumatologie, CHU de Rennes, Rennes, France.
³ Département d'urologie, clinique Saint-Roch Montpellier, Montpellier, France.
⁴ Département d'orthopédie, clinique Saint-Roch Montpellier, Montpellier, France.

PMID: 39426569
DOI: 10.1016/j.fjurol.2024.102759

Abstract

Introduction: Peyronie's and Dupuytren's diseases are benign but are source of significant functional impairment leading to considerable suffering. In this study, the aim is to investigate the association between Peyronie's and Dupuytren's diseases as well as their common and specific risk factors.

Material and methods: From July 2022 to March 2024, we conducted a multicentric observational study on 450 patients. Patients followed up for Peyronie's and/or Dupuytren's disease were given a questionnaire that included a consent form, in order to screen one or the other associated disease and explore all risk factors.

Results: Among the 278 patients followed for Dupuytren's disease, 35 (12.3%) had Peyronie's disease. Of the 172 patients with initial Peyronie's disease, 50 (29.1%) were diagnosed with Dupuytren's disease. Eventually, 85 patients had both pathologies (18.9%). High blood pressure was significantly more prevalent in patients with both diseases, compared to subjects with Peyronie's disease only (37.7% vs. 38.4% vs. 24.4%; P=0.02). The same observation was made regarding smoking (62.3% vs. 60.7% vs. 48.8%; P=0.05) and daily alcohol consumption (52.9% vs. 41.7% vs. 35.8%; P=0.04). Patients diagnosed with isolated Dupuytren's disease were more likely to be diabetic (13.6% vs. 9.41%; P=0.42). Blue eyes and family history were significantly more often reported in Dupuytren's patients (33.9% vs. 22.8%; P=0.03; P<0.001). Ledderhose disease was significantly more prevalent in patients with both diseases or isolated Dupuytren's disease (21.2% vs. 12.4% vs. 3.3%; P=0.0003).

Conclusion: This study confirms the association between Peyronie and Dupuytren diseases. Smoking, alcohol daily consumption and hypertension are more prevalent in case of associated diseases. Blue eyes and family history are significantly more frequently found in case of Dupuytren's contracture. More powerful studies including a control group are necessary.

Keywords: Dupuytren contracture; Facteurs de risque; Fibrose; Fibrosis; Maladie de Dupuytren; Maladie de Lapeyronie; Penile induration; Risk factors.