Molecular mechanisms of polarized transport to the apical plasma membrane

Masataka Kunii; Akihiro Harada

doi:10.3389/fcell.2024.1477173

Molecular mechanisms of polarized transport to the apical plasma membrane

Front Cell Dev Biol. 2024 Sep 26:12:1477173. doi: 10.3389/fcell.2024.1477173. eCollection 2024.

Authors

Masataka Kunii¹, Akihiro Harada¹

Affiliation

¹ Department of Cell Biology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.

Abstract

Cell polarity is essential for cellular function. Directional transport within a cell is called polarized transport, and it plays an important role in cell polarity. In this review, we will introduce the molecular mechanisms of polarized transport, particularly apical transport, and its physiological importance.

Keywords: Rab8; apical transport; cell polarity; polarized transport; unconventional transport.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, and Technology of Japan (grant numbers: 17H0622 and 21H02658 to AH, 21K06734 to MK). The funder supported us doing the experiments required for this review.