Implanted cortical neuroprosthetics for speech and movement restoration

J Neurol. 2024 Nov;271(11):7156-7168. doi: 10.1007/s00415-024-12604-w. Epub 2024 Oct 24.

Abstract

Implanted cortical neuroprosthetics (ICNs) are medical devices developed to replace dysfunctional neural pathways by creating information exchange between the brain and a digital system which can facilitate interaction with the external world. Over the last decade, researchers have explored the application of ICNs for diverse conditions including blindness, aphasia, and paralysis. Both transcranial and endovascular approaches have been used to record neural activity in humans, and in a laboratory setting, high-performance decoding of the signals associated with speech intention has been demonstrated. Particular progress towards a device which can move into clinical practice has been made with ICNs focussed on the restoration of speech and movement. This article provides an overview of contemporary ICNs for speech and movement restoration, their mechanisms of action and the unique ethical challenges raised by the field.

Keywords: Brain–computer interface; Motor neuroprosthesis; Neurological disease; Neuromotor prosthesis; Neuroprosthetic; Neurotechnology.

Publication types

  • Review

MeSH terms

  • Brain-Computer Interfaces*
  • Cerebral Cortex / physiology
  • Cerebral Cortex / physiopathology
  • Humans
  • Movement / physiology
  • Movement Disorders / physiopathology
  • Movement Disorders / therapy
  • Neural Prostheses
  • Speech / physiology
  • Speech Disorders / etiology
  • Speech Disorders / physiopathology
  • Speech Disorders / therapy