Glycine-Induced Hypo-Osmolar Hyponatremia and Hyperammonemia: A Case Report of Operative Hysteroscopy Intravascular Absorption (OHIA) Syndrome

Cureus. 2024 Sep 25;16(9):e70176. doi: 10.7759/cureus.70176. eCollection 2024 Sep.

Abstract

We discuss a case of a 35-year-old female with no known medical conditions, who developed symptoms of confusion, disorientation, and seizures after an uncomplicated hysteroscopic myomectomy of her uterine fibroid using 1.5% glycine solution under general anesthesia (GA). Thanks to prompt diagnosis, management, and periodic follow-up of the patient, her symptoms resolved within 72 hours after the involvement of a multidisciplinary team. Hypo-osmolar hyponatremia with hyperammonemia is a serious and fatal metabolic disturbance seen in patients with glycine intoxication and it requires urgent treatment.

Keywords: cerebral edema; fatal; glycine; hyperammonemia; hyponatremia; leiomyoma; polyuria; seizure.

Publication types

  • Case Reports