Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans

Ian C Fischer; Peter J Na; Sheila T Nagamatsu; Dilip V Jeste; Brenda Cabrera-Mendoza; Janitza L Montalvo-Ortiz; John H Krystal; Renato Polimanti; Joel Gelernter; Robert H Pietrzak

doi:10.1001/jamapsychiatry.2024.3403

Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans

JAMA Psychiatry. 2024 Oct 30:e243403. doi: 10.1001/jamapsychiatry.2024.3403. Online ahead of print.

Authors

Ian C Fischer^{1

2}, Peter J Na^{2

3}, Sheila T Nagamatsu^{2

3}, Dilip V Jeste⁴, Brenda Cabrera-Mendoza^{2

3}, Janitza L Montalvo-Ortiz^{1

2}, John H Krystal^{1

2}, Renato Polimanti^{2

3}, Joel Gelernter^{1

2}, Robert H Pietrzak^{1

2

5}

Affiliations

¹ US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven.
² Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
³ VA Connecticut Healthcare System, West Haven, Connecticut.
⁴ Global Research Network on Social Determinants of Mental Health and Exposomics, La Jolla, California.
⁵ Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, Connecticut.

PMID: 39476130
PMCID: PMC11581715 (available on 2025-10-30)
DOI: 10.1001/jamapsychiatry.2024.3403

No abstract available

Plain language summary

This cross-sectional study uses data from 1135 male, European-American US military veterans to assess whether risk and protective factors influenced associations between posttraumatic stress disorder and epigenetic age.