Brain Tumor Assessment: Integrating PET/Computed Tomography and MR Imaging Modalities

PET Clin. 2025 Jan;20(1):165-174. doi: 10.1016/j.cpet.2024.09.003. Epub 2024 Oct 29.

Abstract

While MR imaging is the main imaging modality to assess brain tumors, PET imaging has a specific role. Among the many tracers that have been proposed and are still being developed, 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) and O-(2-[18F]-fluoroethyl)-l-tyrosine ([18F]FET) PET remain the most solidly established in the clinics. In particular, [18F]FET has gained increased acceptance due to its higher sensitivity. In this paper, we present an overview of the current clinical status of brain tumor imaging, with emphasis on PET imaging.

Keywords: Brain tumors; FAPI; FDG; FET; Neuro-oncology; Radiomics.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging
  • Brain Neoplasms* / diagnostic imaging
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Multimodal Imaging / methods
  • Positron Emission Tomography Computed Tomography* / methods
  • Positron-Emission Tomography / methods
  • Radiopharmaceuticals

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18