Using Simulation to Optimize the Design of Adaptive Clinical Trials

J Am Soc Nephrol. 2024 Oct 31. doi: 10.1681/ASN.0000000565. Online ahead of print.

Cal H Robinson^{1

2

3}, Rulan S Parekh^{1

2

3

4}, Brian H Cuthbertson^{5

6

7}, Eddy Fan⁵, Yongdong Ouyang^{3

8}, Anna Heath^{3

8

9}

¹ Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.
² Department of Paediatrics, The University of Toronto, Toronto, Ontario, Canada.
³ Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
⁴ Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada.
⁵ Interdepartmental Division of Critical Care Medicine, The University of Toronto, Ontario, Canada.
⁶ Sunnybrook Health Sciences Centre Research Institute, Toronto, Ontario, Canada.
⁷ Department of Critical Care Medicine, Sunnybrook Health Sciences Centres, Toronto, Canada.
⁸ Division of Biostatistics, Dalla Lana School of Public Health, The University of Toronto, Toronto, Ontario, Canada.
⁹ Department of Statistical Science, University College London, London, UK.

No abstract available