Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor-Node-Metastasis Stages

Cancer Res Commun. 2024 Nov 1;4(11):3025-3035. doi: 10.1158/2767-9764.CRC-24-0270.

Abstract

The identification of specific spatial patterns of immune checkpoint expression that correlate with overall survival in patients with colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way for the development of novel therapeutic strategies to enhance antitumor immune responses.

MeSH terms

  • Aged
  • Biomarkers, Tumor
  • Colorectal Neoplasms* / immunology
  • Colorectal Neoplasms* / mortality
  • Colorectal Neoplasms* / pathology
  • Female
  • Humans
  • Immune Checkpoint Proteins / genetics
  • Immune Checkpoint Proteins / metabolism
  • Lymphatic Metastasis / pathology
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis

Substances

  • Immune Checkpoint Proteins
  • Biomarkers, Tumor