Impact of smoking cessation on metabolic parameters and renal function in patients with and without diabetes mellitus

C-P Fu; P-K Fu; M-C Lu; Y-Y Liao; J-S Wang

doi:10.1016/j.rceng.2024.10.010

Impact of smoking cessation on metabolic parameters and renal function in patients with and without diabetes mellitus

Rev Clin Esp (Barc). 2024 Nov 1:S2254-8874(24)00140-1. doi: 10.1016/j.rceng.2024.10.010. Online ahead of print.

Authors

C-P Fu¹, P-K Fu², M-C Lu³, Y-Y Liao⁴, J-S Wang⁵

Affiliations

¹ Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
² Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Smoking Cessation Treatment and Management Center, Taichung Veterans General Hospital, Taichung, Taiwan.
³ Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
⁴ Smoking Cessation Treatment and Management Center, Taichung Veterans General Hospital, Taichung, Taiwan.
⁵ Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan; Diabetes Center, Taichung Veterans General Hospital, Taichung, Taiwan. Electronic address: jswang@vghtc.gov.tw.

PMID: 39489462
DOI: 10.1016/j.rceng.2024.10.010

Abstract

Backgroud and objectives: As patients with diabetes are at a significantly higher risk of cardiovascular diseases than those without diabetes, it is important to gain a clinical understanding of the differential effects of smoking cessation on several risk factors between patients with and without diabetes.

Materials and methods: Patients who participated in a smoking cessation program received an assessment of the outcomes of interest. The outcomes were changes in metabolic parameters and renal function from baseline to 6-month follow-up after the smoking cessation program.

Result: A total of 1954 patients joined the smoking cessation program, and 1381 patients were in the smoking cessation failure (SCF) group and 573 were in the smoking cessation success (SCS) group. The decrease in HbA1c after smoking cessation was only observed in patients with diabetes. Smoking cessation was also associated with a significant decrease in LDL cholesterol in patients with diabetes. In terms of renal function, smoking cessation was associated with an improvement in eGFR, and the trend was similar in patients with and without diabetes.

Conclusion: Successful smoking cessation was associated with improvement in renal function. Moreover, it was associated with improvements in HbA1c and LDL cholesterol in patients with diabetes, despite significant weight gain.

Keywords: Body weight; Chronic kidney disease; Dejar de fumar; Diabetes mellitus; Enfermedad renal crónica; Glycated hemoglobin; Hemoglobina glucosilada; Peso corporal; Smoking cessation.