Management of de novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) and the role of Radiotherapy: A Consensus by the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

Andrea Lancia; Anna Rita Alitto; Giovanni Pappagallo; Elisa Ciurlia; Giulio Francolini; Rolando D'Angelillo; Sergio Fersino; Niccolò Giaj Levra; Barbara Alicja Jereczek-Fossa; Alessandro Magli; Francesco Pasqualetti; Alessia Reali; Corrado Spatola; Luca Triggiani

doi:10.1016/j.prro.2024.10.007

Management of de novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) and the role of Radiotherapy: A Consensus by the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

Pract Radiat Oncol. 2024 Oct 26:S1879-8500(24)00287-X. doi: 10.1016/j.prro.2024.10.007. Online ahead of print.

Authors

Affiliations

¹ Department of Radiation Oncology, Policlinico San Matteo Pavia Fondazione IRCCS, Pavia, Italy. Electronic address: andrea.lancia.dr@gmail.com.
² UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
³ School of Methodology of Clinical Research, IRCCS "Sacro Cuore-Don Calabria" Hospital, 37024 Negrar di Valpolicella, VR, Italy.
⁴ Department of Radiation Therapy, "Vito Fazzi" Hospital, 73100 Lecce, Italy.
⁵ Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.
⁶ Radiotherapy, Department of Oncoematology, Policlinico Tor Vergata, 00133 Rome, Italy.
⁷ Department of Radiation Therapy, S.Chiara Hospital, Trento.
⁸ Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don-Calabria, Negrar di Valpolicella, Italy.
⁹ Division of Radiation Oncology, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
¹⁰ Department of Radiation Therapy, AULSS1-Dolomiti, S.Martino Hospital, Belluno.
¹¹ Department of Radiation Oncology, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Tuscany, Italy.
¹² Radiation Oncology Department, Michele e Pietro Ferrero Hospital, Verduno.
¹³ Radiation Oncology Unit, Department of Medical Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.
¹⁴ Radiation Oncology Unit, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

PMID: 39490734
DOI: 10.1016/j.prro.2024.10.007

Abstract

Background and objectives: Prostate cancer treatments paradigms are in continuous evolution, especially in metastatic setting. In this context, the Genito-Urinary (GU) Group of Italian Association of Radiotherapy and Clinical Oncology (AIRO) aimed to create a Consensus on radiotherapy indication in de novo metastatic hormone sensitive prostate cancer both on primary tumour and metastatic sites.

Methods: A panel of experts, involved in clinical management of prostate cancer, through the estimate-talk-estimate (ETE) method, developed a list of items and correspondent statements on the identified topic.

Key findings: Seven conclusive items were identified with 12 statements about the chosen topic, radiotherapy in metastatic hormone sensitive prostate cancer on primary tumour and metastatic sites.

Conclusions and clinical implications: This consensus might help clinicians in prostate cancer managing in daily clinical practice.

Keywords: Consensus; Metastatic Hormone sensitive; Prostate Cancer; Radiotherapy.