Neuromelioidosis - A retrospective review of thirteen cases from a tertiary care centre from South India

Indian J Med Microbiol. 2024 Nov 4:52:100751. doi: 10.1016/j.ijmmb.2024.100751. Online ahead of print.

Abstract

Neurologic melioidosis warrants attention in view of its rarity and lethal consequences. We performed a retrospective review of culture confirmed neurologic melioidosis reported between 2017 and 2023. Thirteen patients were identified with median age 43 years and all but three were males. Brain parenchyma was involved in 57 % cases (7/13) as cerebritis, encephalitis and macro abscess or micro abscess. Three patients had myelitis with spinal cord micro abscess and cerebral venous thrombosis in three other patients. Five patients died during hospitalization. Two were discharged against medical advice due to financial constraints. Six survivors were followed between one and eight months.

Keywords: Acute encephalitis; Cerebral venous thrombosis; MR venogram; MRI; Melioidosis; Meningitis.