A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review

Yuzhan Chen; Ting Chen; Shufang Fan; Qitian Mu; Guifang Ouyang

doi:10.1007/s00277-024-06080-5

A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review

Ann Hematol. 2024 Nov 4. doi: 10.1007/s00277-024-06080-5. Online ahead of print.

Authors

Yuzhan Chen^{1

2}, Ting Chen¹, Shufang Fan^{1

2}, Qitian Mu³, Guifang Ouyang⁴

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, P. R. China.
² Health Science Center, Ningbo University, Ningbo, 315000, China.
³ Laboratory of Stem Cell Transplantation, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, China.
⁴ Department of Hematology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, 315000, P. R. China. fyyouyangguifang@nbu.edu.cn.

PMID: 39495282
DOI: 10.1007/s00277-024-06080-5

Abstract

In indolent lymphomas, histological transformation (HT) often results in a poor prognosis and presents a significant challenge in the management of these lymphomas. Previous studies have indicated that MYD88 mutations are associated with transformation in certain haematologic malignancies. We report a rare case of splenic marginal zone lymphoma (SMZL) harbouring an MYD88 mutation, which was transformed into diffuse large B-cell lymphoma (DLBCL) and accompanied by newly emerging genetic abnormalities. The role of the MYD88 gene in SMZL is currently unclear. Through this case, we reviewed relevant studies, which indicated that MYD88 mutations, along with other genetic anomalies, may play a significant role in this process. In the future, it is essential to collect more of these rare cases for further research.

Keywords: Diffuse large B-cell lymphoma; Histological transformation; MYD88 mutation; Splenic marginal zone lymphoma.

Abstract

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