Association of Social Determinants of Health With Hospital Readmission and Mortality: A Prospective Cohort Study

Health Lit Res Pract. 2024 Oct;8(4):e212-e223. doi: 10.3928/24748307-20240702-01. Epub 2024 Nov 1.

Abstract

Background: The relative contributions of common patient-reported social determinants of health on 30- and 90-day post-discharge outcomes among patients with acute coronary syndromes (ACS) is unclear.

Objective: The aim of this article is to examine the independent associations of social determinants with readmission or death, accounting for medical history.

Methods: Participants included adults who were hospitalized with ACS at an academic medical center. Domains measured were social support, health literacy/numeracy, and socioeconomic status (SES) (including education and difficulty paying bills). We employed multivariable Cox proportional hazard models to study associations with time to all-cause readmission or death, up to 30 or 90 days after discharge, and adjusted for demographics and medical history (prior admissions and Elixhauser comorbidity index).

Key results: Among 1,168 patients with ACS and no history of heart failure, more prior admissions, and higher comorbidity index (the medical history domain) were associated with higher rates of 30- and 90-day readmission or death (domain p values <.01 and <.0001, respectively). The social support domain was not associated with outcomes. Higher health literacy and numeracy were associated with lower rates of 30- and 90-day readmission or death (domain p values .016 and .002, respectively). Higher education and less difficulty paying bills (the SES domain) was marginally associated with lower rates of 90-day readmission or death (domain, p = .052).

Conclusions: In addition to medical history, the domain of health literacy and numeracy was independently associated with readmission or death of patients with ACS during the 90 days after hospital discharge. [HLRP: Health Literacy Research and Practice. 2024;8(4):e212-e223.].

Plain language summary

Plain Language Summary In this study of patients admitted to the hospital with heart conditions, we asked them about their social support, how they understood health information (health literacy), economic status, education, and difficulty paying bills. We found that patients with higher health literacy had less returns to the hospital or died less frequently within 30 and 90 days of their initial stay.

MeSH terms

  • Acute Coronary Syndrome* / mortality
  • Adult
  • Aged
  • Female
  • Health Literacy* / standards
  • Health Literacy* / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Patient Discharge / statistics & numerical data
  • Patient Readmission* / statistics & numerical data
  • Proportional Hazards Models
  • Prospective Studies
  • Social Class
  • Social Determinants of Health* / statistics & numerical data
  • Social Support

Grants and funding

Funding: This study was supported by grant R01 HL109388 from the National Heart, Lung, and Blood Institute and in part by grants UL1 TR000445-06 from the National Center for Advancing Translational Sciences, K23AG048347 from the Eisenstein Women's Heart Fund, and K23AG040157 from the National Institute on Aging. ASM was supported by a Veterans Affairs Health Services Research and Development Service Career Development Award at the Tennessee Valley Healthcare System, Department of Veterans Affairs (CDA 12-168).