The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Aihong Peng; Junqin Li; Jianxiao Xing; Yuanjun Yao; Xuping Niu; Kaiming Zhang

doi:10.3389/fmolb.2024.1480617

The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Front Mol Biosci. 2024 Oct 24:11:1480617. doi: 10.3389/fmolb.2024.1480617. eCollection 2024.

Authors

Aihong Peng¹, Junqin Li¹, Jianxiao Xing¹, Yuanjun Yao¹, Xuping Niu¹, Kaiming Zhang¹

Affiliation

¹ Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan Center Hospital, Taiyuan, China.

Abstract

Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis. NAMPT synthesizes nicotinamide mononucleotide (NMN) through enzymatic action, which is a key protein involved in host defense mechanism and plays an important role in metabolic homeostasis and cell survival. NAMPT is involved in NAD metabolism and maintains intracellular NAD levels. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs), the members are capable of sensing cellular NAD+ levels. NAMPT-NAD and SIRT constitute a powerful anti-stress defense system. In this paper, the structure, biological function and correlation with diseases of NAMPT are introduced, aiming to provide new ideas for the targeted therapy of related diseases.

Keywords: NAD metabolism; NAMPT; SIRTs; biological function; diseases.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Grant No. 82273539) and the Basic Research Project of Shanxi Province (Grant No. 202203021222412 and 202203021212021).