Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review

Nutrients. 2024 Oct 30;16(21):3709. doi: 10.3390/nu16213709.

Abstract

Diabetes mellitus (DM) is currently regarded as a global public health crisis for which lifelong treatment with conventional drugs presents limitations in terms of side effects, accessibility, and cost. Type 2 diabetes (T2DM), usually associated with obesity, is characterized by elevated blood glucose levels, hyperlipidemia, chronic inflammation, impaired β-cell function, and insulin resistance. If left untreated or when poorly controlled, DM increases the risk of vascular complications such as hypertension, nephropathy, neuropathy, and retinopathy, which can be severely debilitating or life-threatening. Plant-based foods represent a promising natural approach for the management of T2DM due to the vast array of phytochemicals they contain. Numerous epidemiological studies have highlighted the importance of a diet rich in plant-based foods (vegetables, fruits, spices, and condiments) in the prevention and management of DM. Unlike conventional medications, such natural products are widely accessible, affordable, and generally free from adverse effects. Integrating plant-derived foods into the daily diet not only helps control the hyperglycemia observed in DM but also supports weight management in obese individuals and has broad health benefits. In this review, we provide an overview of the pathogenesis and current therapeutic management of DM, with a particular focus on the promising potential of plant-based foods.

Keywords: diabetes; dietary adjuncts; glucose; insulin; medicinal plants; phytoconstituents.

Publication types

  • Review

MeSH terms

  • Diabetes Complications / prevention & control
  • Diabetes Mellitus, Type 2* / diet therapy
  • Diet, Plant-Based
  • Diet, Vegetarian*
  • Fruit
  • Humans
  • Obesity
  • Phytochemicals* / administration & dosage
  • Vegetables

Substances

  • Phytochemicals

Grants and funding

Research conducted over many years in the authors’ laboratories and referred to in the text was supported by Diabetes UK, NI, Department of Health and Social Services, SAAD Trading Company, and Ulster University Strategic Funding.