Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis

Zi Ye; Leilei Yu; Dezhi Lu; Qingsong Zhang; Arjan Narbad; Wei Chen; Qixiao Zhai; Fengwei Tian

doi:10.1016/j.jhazmat.2024.136401

Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis

J Hazard Mater. 2024 Nov 5:480:136401. doi: 10.1016/j.jhazmat.2024.136401. Online ahead of print.

Authors

Zi Ye¹, Leilei Yu¹, Dezhi Lu¹, Qingsong Zhang¹, Arjan Narbad², Wei Chen³, Qixiao Zhai¹, Fengwei Tian⁴

Affiliations

¹ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
² Gut Health and Microbiome Institute Strategic Programme, Quadram Institute Bioscience, Norwich, UK; International Joint Research Laboratory for Pharmabiotics & Antibiotic Resistance, Jiangnan University, Wuxi, Jiangsu 214122, China.
³ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China.
⁴ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: fwtian@jiangnan.edu.cn.

PMID: 39522148
DOI: 10.1016/j.jhazmat.2024.136401

Abstract

Nonylphenol (NP), an endocrine-disrupting compound (EDC) with accumulative properties, poses significant risks to human health and the environment. The pivotal role of probiotics in mitigating EDC toxicity has garnered increasing attention. In this study, we assessed the protective effects of Bifidobacterium longum CCFM1077, a probiotic with outstanding in vitro NP-binding ability, against NP-induced toxicity in rats. This analysis revealed that B. longum CCFM1077 effectively promoted the NP excretion and enhanced intestinal barrier integrity. Interestingly, B. longum CCFM1077, by modulating the structure and the function of gut microbiota, increased the abundance of Turicibacter, significantly elevated the level of butyric acid, and upregulated antioxidant-related metabolic pathways, thereby alleviating brain inflammation and ultimately improving behavioral disorders. This study elucidated a strategy to alleviate NP toxicity and lays a theoretical foundation for the development of novel intestinal protection strategies. It supports environmental sustainability by offering a strategy to combat NP bioaccumulation, aligning with global initiatives to minimize the environmental impact of industrial pollutants.

Keywords: Bifidobacterium longum; Butyric acid; Gut barrier; Gut microbiota; Nonylphenol exposure.