Declaration of Computational Neurosurgery

Antonio Di Ieva; Eric Suero Molina; Margaret A Somerville; Amin Beheshti; Victor E Staartjes; Carlo Serra; Nicholas Theodore; James M Elliott; Evert O Wesselink; Carlo Russo; Julie G Pilitsis; Christine C Bennett; Shandong Wu; Flora M Hammond; Andres M Lozano; Michael D Cusimano; Jennilee M Davidson; James F Castellano; David O Okonkwo; Dooman Arefan; Cheng-Chia Lee; Olivier Zanier; Raffaele Da Mutten; Christian Matula; James T Rutka; Matthew Pease; Sidong Liu; Walter Stummer; Rita Matulionyte; Hongxi Yang; Chang Yuwen; Xuelian Cheng; Hengwei Fan; Xin Wang; Zongyuan Ge; Santiago Cepeda; Jason P Sheehan; Joseph Yuan-Mou Yang; Ryan P Hamer; Aaron Cohen-Gadol; Jordan R Hansford; Greg Savage; Paul F Sowman; Caleb Stewart; Babak Kateb; Camillo Sherif; Antonios Perperidis; Anna Guller; Simon Hanft; Randy S D'Amico; Aydin Sav; Cong Cong; Yang Song; Federico Nicolosi; Marcus K H Wiedmann; Damiano G Barone; Imran Noorani; John Magnussen; Sandro M Krieg; Torstein R Meling; Dirk De Ridder; Michael T Lawton; Jeffrey V Rosenfeld

doi:10.1007/978-3-031-64892-2_2

Declaration of Computational Neurosurgery

Adv Exp Med Biol. 2024:1462:11-20. doi: 10.1007/978-3-031-64892-2_2.

Authors

Antonio Di Ieva^{1

2

3}, Eric Suero Molina^{4

5

6}, Margaret A Somerville^{7

8}, Amin Beheshti⁹, Victor E Staartjes¹⁰, Carlo Serra¹⁰, Nicholas Theodore¹¹, James M Elliott¹², Evert O Wesselink¹³, Carlo Russo⁴, Julie G Pilitsis¹⁴, Christine C Bennett⁷, Shandong Wu¹⁵, Flora M Hammond¹⁶, Andres M Lozano^{17

18}, Michael D Cusimano¹⁹, Jennilee M Davidson⁴, James F Castellano²⁰, David O Okonkwo²¹, Dooman Arefan¹⁵, Cheng-Chia Lee²², Olivier Zanier¹⁰, Raffaele Da Mutten¹⁰, Christian Matula²³, James T Rutka²⁴, Matthew Pease²⁵, Sidong Liu^{4

26}, Walter Stummer⁶, Rita Matulionyte²⁷, Hongxi Yang²⁸, Chang Yuwen²⁹, Xuelian Cheng^{30

31}, Hengwei Fan³², Xin Wang³², Zongyuan Ge^{28

33}, Santiago Cepeda³⁴, Jason P Sheehan³⁵, Joseph Yuan-Mou Yang^{36

37

38}, Ryan P Hamer^{39

40}, Aaron Cohen-Gadol^{41

25}, Jordan R Hansford^{42

43

44}, Greg Savage⁴⁵, Paul F Sowman^{46

47}, Caleb Stewart^{4

48}, Babak Kateb^{49

50

51

52}, Camillo Sherif^{53

54}, Antonios Perperidis^{55

56}, Anna Guller^{4

57

58}, Simon Hanft⁵⁹, Randy S D'Amico⁶⁰, Aydin Sav⁶¹, Cong Cong^{4

26

62}, Yang Song⁶², Federico Nicolosi⁶³, Marcus K H Wiedmann⁶⁴, Damiano G Barone⁶⁵, Imran Noorani^{66

67}, John Magnussen⁴, Sandro M Krieg⁶⁸, Torstein R Meling⁶⁹, Dirk De Ridder^{70

71}, Michael T Lawton⁷², Jeffrey V Rosenfeld^{73

74}

Affiliations

¹ Computational NeuroSurgery (CNS) Lab, Macquarie Medical School, Faculty of Medicine, Human and Health Sciences, Macquarie University, Sydney, NSW, Australia. Antonio.diieva@mq.edu.au.
² Macquarie Neurosurgery & Spine, MQ Health, Macquarie University Hospital, Sydney, NSW, Australia. Antonio.diieva@mq.edu.au.
³ Department of Neurosurgery, Nepean Blue Mountains Local Health District, Kingswood, NSW, Australia. Antonio.diieva@mq.edu.au.
⁴ Computational NeuroSurgery (CNS) Lab, Macquarie Medical School, Faculty of Medicine, Human and Health Sciences, Macquarie University, Sydney, NSW, Australia.
⁵ Macquarie Neurosurgery & Spine, MQ Health, Macquarie University Hospital, Sydney, NSW, Australia.
⁶ Department of Neurosurgery, University Hospital of Münster, Münster, Germany.
⁷ School of Medicine, The University of Notre Dame Australia, Sydney, NSW, Australia.
⁸ Faculty of Law and Faculty of Medicine, McGill University, Montreal, QC, Canada.
⁹ School of Computing, Macquarie University, Sydney, NSW, Australia.
¹⁰ Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
¹¹ Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹² The Kolling Institute, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.
¹³ Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
¹⁴ Department of Neurosurgery, University of Arizona, Tucson, AZ, USA.
¹⁵ Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
¹⁶ Department of Physical Medicine & Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.
¹⁷ Division of Neurosurgery, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
¹⁸ Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁹ Division of Neurosurgery, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Department of Surgery, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
²⁰ Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
²¹ Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
²² Neurological Institute Department of Functional Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan.
²³ Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
²⁴ Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
²⁵ Department of Neurological Surgery, Indiana University, Indianapolis, IN, USA.
²⁶ Centre for Health Informatics, Australian Institute of Health Innovation, Faculty of Medicine, Human and Health Sciences, Macquarie University, Sydney, NSW, Australia.
²⁷ Macquarie Law School, Macquarie University, Sydney, NSW, Australia.
²⁸ Faculty of Information Technology, Monash University, Melbourne, VIC, Australia.
²⁹ Faculty of Engineering, Monash University, Melbourne, VIC, Australia.
³⁰ Monash Suzhou Research Institute, Monash University, Suzhou, China.
³¹ Department of Data Science & Artificial Intelligence (DSAI), Monash University, Clayton, VIC, Australia.
³² Shukun (Beijing) Technology Co, Beijing, China.
³³ The AIM for Health Lab, Monash, Melbourne, VIC, Australia.
³⁴ Department of Neurosurgery, Río Hortega University Hospital, Valladolid, Spain.
³⁵ Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.
³⁶ Neuroscience Advanced Clinical Imaging Service (NACIS), Department of Neurosurgery, Royal Children's Hospital, Melbourne, VIC, Australia.
³⁷ Neuroscience Research, Murdoch Children's Research Institute Melbourne, Parkville, VIC, Australia.
³⁸ Deparment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
³⁹ Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
⁴⁰ Department of Surgery, St Vincent's Hospital, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
⁴¹ The Neurosurgical Atlas, Carmel, IN, USA.
⁴² Michael Rice Centre for Haematology and Oncology, Women's and Children's Hospital, North Adelaide, SA, Australia.
⁴³ South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
⁴⁴ South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia.
⁴⁵ School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
⁴⁶ Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
⁴⁷ School of Clinical Sciences, Auckland University of Technology, Auckland, Aotearoa, New Zealand.
⁴⁸ Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
⁴⁹ Brain Technology and Innovation Park, Los Angeles, CA, USA.
⁵⁰ World Brain Mapping Foundation, Pacific Palisades, CA, USA.
⁵¹ Society for Brain Mapping and Therapeutics (SBMT), Pacific Palisades, CA, USA.
⁵² National Center for NanoBioElectronics, Los Angeles, CA, USA.
⁵³ Karl Landsteiner University of Health Sciences; Department of Neurosurgery, University Hospital St. Pölten; Cerebrovascular Research Group, Department of Neurosurgery, University Hospital St. Pölten, Sankt Poelten, Austria.
⁵⁴ Cerebrovascular Research Group, Department of Neurosurgery, University Hospital St. Pölten, Sankt Poelten, Austria.
⁵⁵ Australian Institute for Machine Learning, University of Adelaide, Adelaide, SA, Australia.
⁵⁶ Women's and Children's Hospital, Adelaide, SA, Australia.
⁵⁷ ARC Centre of Excellence for Nanoscale Biophotonics, Sydney, NSW, Australia.
⁵⁸ The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia.
⁵⁹ Department of Neurosurgery, Westchester Medical Center, Valhalla, NY, USA.
⁶⁰ Department of Neurosurgery, Northwell, Health System, New York, NY, USA.
⁶¹ Department of Medical Pathology, Yeditepe University, Istanbul, Turkey.
⁶² School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia.
⁶³ Department of Medicine and Surgery, University of Milano Bicocca, Milan, Italy.
⁶⁴ Deparment of Neurosurgery, Oslo University Hospital, Oslo, Norway.
⁶⁵ Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
⁶⁶ Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
⁶⁷ Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK.
⁶⁸ Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
⁶⁹ Department of Neurosurgery, The National Hospital, Rigshospitalet, Copenhagen, Denmark.
⁷⁰ Section of Neurosurgery, Department of Surgical Sciences, University of Otago, Dunedin, New Zealand.
⁷¹ Department of Stereotactic and Functional Neurosurgery, University Hospital Bonn, Bonn, Germany.
⁷² Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
⁷³ Department of Neurosurgery, Alfred Hospital, Melbourne, VIC, Australia.
⁷⁴ Department of Surgery, Monash University, Clayton, VIC, Australia.

PMID: 39523257
DOI: 10.1007/978-3-031-64892-2_2

Abstract

Computational neurosurgery is a novel and disruptive field where artificial intelligence and computational modeling are used to improve the diagnosis, treatment, and prognosis of patients affected by diseases of neurosurgical relevance. The field aims to bring new knowledge to clinical neurosciences and inform on the profound questions related to the human brain by applying augmented intelligence, where the power of artificial intelligence and computational inference can enhance human expertise. This transformative field requires the articulation of ethical considerations that will enable scientists, engineers, and clinical neuroscientists, including neurosurgeons, to ensure that the use of such a powerful application is conducted based on the highest moral and ethical standards with a patient-centric approach to predict and prevent mistakes. This declaration is a first attempt to draw a roadmap to guide the application of practical or applied ethics to computational neurosurgery. It is intended for the use of practitioners, ethicists, and scientists using artificial intelligence to understand and treat all the pathophysiological conditions related to the human brain.

Keywords: Artificial intelligence; Computational neurosurgery; Declaration; Ethics; Neurotechnology; Pillars.

MeSH terms

Artificial Intelligence* / ethics
Brain / physiology
Brain / surgery
Computational Biology / ethics
Computational Biology / methods
Computer Simulation
Humans
Neurosurgery* / ethics
Neurosurgery* / methods
Neurosurgical Procedures / ethics
Neurosurgical Procedures / methods