Hazardous alcohol consumption is associated with an increased occurrence of falls among people with HIV in the PROSPER-HIV Study

Andre P Dos Santos; Amanda L Willig; Stephanie Ruderman; Vitor H F Oliveira; Christine Horvat Davey; Thomas W Buford; Dustin M Long; Barbara Gripshover; Mari Katundu; John D Cleveland; Heidi M Crane; Julia Fleming; Greer Burkholder; Michael S Saag; Allison R Webel

doi:10.1097/QAD.0000000000004061

Hazardous alcohol consumption is associated with an increased occurrence of falls among people with HIV in the PROSPER-HIV Study

AIDS. 2024 Nov 11. doi: 10.1097/QAD.0000000000004061. Online ahead of print.

Authors

Affiliations

¹ University of Washington, Seattle, WA.
² TW Education, Birmingham, AL.
³ Case Western Reserve University, Cleveland, OH.
⁴ University of Alabama at Birmingham, Birmingham, AL.
⁵ Fenway Health, Boston, MA.

PMID: 39527778
DOI: 10.1097/QAD.0000000000004061

Abstract

Objective: Falls are a significant public health concern, particularly among older adults and people with HIV (PWH). This study examines the association between alcohol consumption and falls in PWH.

Methods: The PROSPER-HIV study recruited PWH from four US sites. Participants were categorized based on Alcohol Use Disorders Identification Test Consumption (AUDIT-C) scores: none, non-hazardous, and hazardous drinking. Data collection included demographics, medical history (i.e., comorbidities, treated hypertension, eGFR), alcohol consumption using AUDIT-C, daily alcohol recall in grams, and self-reported falls over the previous year. Physical performance was measured using the Short Performance Physical Battery (SPPB). Statistical analyses included Pearson's correlation and Poisson regression models to estimate fall prevalence ratios (PR), adjusting for confounders (SPPB, comorbidities, treated hypertension, and eGFR).

Results: The study included 315 PWH, aged 52 ± 12 years, with 78% male participants. Thirty-three percent were classified as non-drinking, 50% non-hazardous, and 17% hazardous drinking. Poisson regression showed a significantly higher risk of falls (PR: 2.12, 95% CI: 1.11-4.03) and recurrent falls (PR: 3.54, 95% CI: 1.21-10.3) among hazardous drinking compared to non-hazardous drinking, even after adjusting for confounders. The PR for falls per daily intake in grams was not statistically significant.

Conclusions: There is a significant association between hazardous alcohol consumption and increased fall risk in PWH using AUDIT-C, but not when accessing recall of alcohol consumption in grams.