Genomic Epidemiology of Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae in Kenya, Uganda, and Jordan

Emerg Infect Dis. 2024 Oct;30(14):33-40. doi: 10.3201/eid3014.240370.

Abstract

Surveillance of antimicrobial resistance in Kenya, Uganda, and Jordan identified multidrug-resistant high-risk bacterial clones: Escherichia coli sequence types 131, 1193, 69, 167, 10, 648, 410, 405 and Klebsiella pneumoniae sequence types 14, 147, 307, 258. Clones emerging in those countries exhibited high resistance mechanism diversity, highlighting a serious threat for multidrug resistance.

Keywords: Antimicrobial resistance; Escherichia coli; Jordan; Kenya; Klebsiella pneumoniae; Uganda; bacteria; high-risk clones; multidrug resistance.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Drug Resistance, Multiple, Bacterial* / genetics
  • Escherichia coli Infections* / epidemiology
  • Escherichia coli Infections* / microbiology
  • Escherichia coli* / drug effects
  • Escherichia coli* / genetics
  • Escherichia coli* / isolation & purification
  • Genomics / methods
  • Humans
  • Jordan / epidemiology
  • Kenya / epidemiology
  • Klebsiella Infections* / epidemiology
  • Klebsiella Infections* / microbiology
  • Klebsiella pneumoniae* / drug effects
  • Klebsiella pneumoniae* / genetics
  • Microbial Sensitivity Tests*
  • Molecular Epidemiology
  • Uganda / epidemiology

Substances

  • Anti-Bacterial Agents