A CuO/TiO2 hybrid heterostructure was successfully engineered from copper metal-organic frameworks (MOFs) using a two-step process involving solvothermal synthesis and calcination. By precisely controlling the CuO loading, this synergistic composite exhibited exceptional performance in photocatalytic CO2 reduction. Notably, AI-assisted continuous flow experimentation achieved a record-breaking methanol production rate of 2.3 mol g-1 h-1 without the need for sacrificial agents.