Plastic production and plastic pollution negatively affect our environment, environmental justice, and climate change. Using detailed global and regional plastics datasets coupled with socio-economic data, we employ machine learning to predict that, without intervention, annual mismanaged plastic waste will nearly double to 121 Mt (100 - 139 Mt 95% CI) by 2050. Annual greenhouse gas emissions from the plastic system are projected to grow by 37% to 3.35 Gt CO2 equivalent (3.09 - 3.54 CO2e) over the same period. The United Nations plastic pollution treaty presents a unique opportunity to reshape these outcomes. We simulate eight candidate treaty policies and find that just four could together reduce mismanaged plastic waste by 91% (86% - 98%) and gross plastic-related greenhouse gas emissions by one third.