Direct Convective Delivery for Nervous System Gene Therapy

Abstract

Convection-enhanced delivery for central nervous system gene therapy is an emerging treatment strategy to modify the course of previously untreatable or inadequately treated neurologic conditions, including brain tumors, metabolic disorders, epilepsy, and neurodegenerative disorders. Ongoing nervous system gene therapy clinical trials highlight advantages and ongoing challenges to this therapeutic paradigm.

Keywords: Convection-enhanced delivery; Gene therapy; Infusion; Magnetic resonance imaging; Neurologic disorder; Surgery; Treatment.