A Rare Case of Pulmonary Edema Secondary to Hydrochlorothiazide Use

Evan J Chen; Laurie Hayrapetian; Katherine Frishe

doi:10.1155/2024/9423545

A Rare Case of Pulmonary Edema Secondary to Hydrochlorothiazide Use

Case Rep Crit Care. 2024 Nov 7:2024:9423545. doi: 10.1155/2024/9423545. eCollection 2024.

Authors

Evan J Chen^{1

2}, Laurie Hayrapetian^{1

2}, Katherine Frishe¹

Affiliations

¹ Department of Internal Medicine, Los Angeles General Medical Center, Los Angeles, California, USA.
² Department of Internal Medicine, Keck Hospital of USC, Los Angeles, California, USA.

Abstract

Noncardiogenic pulmonary edema has been reported as a rare adverse reaction of hydrochlorothiazide. Symptoms can develop acutely after medication ingestion, and patients may present acutely ill. The mechanism by which hydrochlorothiazide causes pulmonary edema remains unknown and is considered idiosyncratic. Prompt supportive care and discontinuation of the medication is necessary to prevent and manage such a complication. This case report describes a patient who developed noncardiogenic pulmonary edema after taking a combination pill of hydrochlorothiazide-losartan.

Keywords: hydrochlorothiazide; idiosyncratic drug reaction; medication side effects; noncardiogenic pulmonary edema; thiazide diuretics.

Publication types

Case Reports