Genetic polymorphism of the CYP11B2 gene in an Iraqi patient with essential hypertension

Wiad Lek. 2024;77(9):1726-1732. doi: 10.36740/WLek/191330.

Abstract

Objective: Aim: To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their ef f ect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province.

Patients and methods: Materials and Methods: This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist. There was a total of 90 participants, 37 males and 53 women. Aldosterone and renine levels in the plasma were determined from blood samples given voluntarily by patients undergoing genetic testing.

Results: Results: Regarding rs4539 the most frequent allele was T (112, 62%) while the most frequent genotype was TC (54, 60%). Regarding rs1799998 the most frequent allele was G (97, 54%) while the most frequent genotype was AG (49, 54%).

Conclusion: Conclusions: There was no signif i cant relationship between rs1799998 (A344>G) and rs4539 (T2718C) with systolic and diastolic blood pressure in Iraqi patient with essential hypertension.

Keywords: CYP11B2 gen; polymorphism; Iraq; essential hypertension.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Blood Pressure / genetics
  • Cross-Sectional Studies
  • Cytochrome P-450 CYP11B2* / genetics
  • Essential Hypertension* / genetics
  • Female
  • Humans
  • Iraq
  • Male
  • Middle Aged
  • Polymorphism, Genetic

Substances

  • Cytochrome P-450 CYP11B2