Three evidence-based psychotherapies for depression (D-EBPs)-cognitive behavioral therapy for depression, acceptance and commitment therapy for depression, and interpersonal psychotherapy-are available in Veterans Health Administration (VHA) through its training initiative. However, training initiatives are not sufficient to move effective treatments into routine practice. Patient and clinic factors can impact evidence-based psychotherapies use. As part of a larger explanatory sequential mixed methods study, we assessed D-EBP use across VHA's outpatient general mental health (GMH) clinics and examined associations between patient- and clinic-level factors and D-EBP use. We identified all patients with a depression diagnosis seen in a VHA GMH clinic in fiscal year 2022. Patient-level variables included demographics, psychiatric medication for depression, and comorbid mental health diagnoses. Clinic-level variables included patient volume, D-EBP clinician capacity, and location. 635,653 patients with a diagnosis of depression were seen in a GMH clinic. 2.8% of those patients had a D-EBP session identified in their medical record, and 77.4% received a depression medication. Being male, older, having certain comorbidities, and using depression medication was associated with lower D-EBP use. Clinics with lower psychotherapy patient volume and in the Continental and Midwest districts had higher D-EBP use. D-EBP use was strikingly lower than depression medication use. Findings suggest clinicians may be challenged by patient comorbidities and high patient volume in practice. Further research on how these factors play out in clinical practice can shed light on whether there is a need for additional implementation strategies to increase D-EBP use. (PsycInfo Database Record (c) 2024 APA, all rights reserved).