Non-coding RNA biosensors for early detection of brain cancer

Yousof Karami; Sajad Ehtiati; Hassan Ghasemi; Maedeh Rafiee; Maryam Zamani Sani; Seyed Edris Hosseini; Hossein Moradi Kazerouni; Ahmad Movahedpour; Saleh Aiiashi; Seyyed Hossein Khatami

doi:10.1016/j.cca.2024.120041

Non-coding RNA biosensors for early detection of brain cancer

Clin Chim Acta. 2024 Nov 17:566:120041. doi: 10.1016/j.cca.2024.120041. Online ahead of print.

Authors

Affiliations

¹ Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
² Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Research Center for Environmental Contaminants (RCEC), Abadan University of Medical Sciences, Abadan, Iran.
⁴ Department of Veterinary Sciences University of Wyoming 1174 Snowy Range Road Laramie, WY 82070, USA.
⁵ Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Resident of Large Animal Internal Medicine, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Iran.
⁷ Abadan University of Medical Sciences, Abadan, Iran.
⁸ Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Electronic address: ahmad.movahed14@gmail.com.
⁹ Abadan University of Medical Sciences, Abadan, Iran. Electronic address: s.aiiashi65@gmail.com.
¹⁰ Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: shossein.khatami@gmail.com.

PMID: 39561887
DOI: 10.1016/j.cca.2024.120041

Abstract

Brain cancer remains a formidable challenge with limited treatment options. Non-coding RNAs (ncRNAs) have emerged as promising biomarkers due to their dysregulation in tumorigenesis. This review explores the potential of biosensors for early detection of brain cancer by targeting ncRNAs. We discuss the classification and functions of ncRNAs, emphasizing their involvement in key cancer-related processes. Additionally, we delve into recent advancements in biosensor technology, focusing on their ability to accurately detect specific ncRNA biomarkers associated with brain cancer. Our findings underscore the potential of biosensors to revolutionize brain cancer diagnosis, enabling personalized medicine and improving patient outcomes. Future research should focus on refining biosensor technology and expanding their clinical application.

Keywords: Biosensor; Brain cancer; Early detection; Non-coding RNA; ncRNA biomarkers.

Publication types

Review