Different levels of lipids, Hb1Ac and cytokines among patients with coronary artery disease

Xue Jiang; Xin-Ying Guo; Jie Zhang; Guo-Yong Zhang; Zheng Ma; Cai-Xia Guo

doi:10.1016/j.heliyon.2024.e39908

Different levels of lipids, Hb1Ac and cytokines among patients with coronary artery disease

Heliyon. 2024 Oct 28;10(21):e39908. doi: 10.1016/j.heliyon.2024.e39908. eCollection 2024 Nov 15.

Authors

Xue Jiang¹, Xin-Ying Guo¹, Jie Zhang¹, Guo-Yong Zhang¹, Zheng Ma¹, Cai-Xia Guo¹

Affiliation

¹ Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, PR China.

Abstract

Background: Different risk factors are responsible for the occurrence of coronary artery disease (CAD). Among these, the main factors are dyslipidemia, dysglycaemia, and endothelial inflammation. The aim of the study was to analyze the levels of lipids, glucose, and cytokine in patients with different coronary heart diseases.

Methods: A total of 2147 patients diagnosed with coronary atherosclerosis, stable angina, unstable angina, acute non-ST-segment elevation infarction (NSTEMI) and acute ST-segment-elevation myocardial infarction (STEMI) at the Cardiovascular Center of Beijing Tongren Hospital from February 2022 to April 2023. The data were gathered from the medical record system.Nonparametric Wilcoxon test was used for statistical analysis of continuous variables, and chi-square test was used for statistical analysis of categorical variables among multiple groups.

Results: Compared with coronary atherosclerosis group, acute myocardial infarction group showed a significant increase in IL-6 level (p < 0.001). Compared with stable angina group, acute myocardial infarction group showed a significant increase in IL-6 and decrease in INF-γlevels (p < 0.001). Compared with unstable angina group, acute myocardial infarction group showed a significant increase in IL-6 level and decrease in IL-17, as well as INF-γlevels (p < 0.001). Compared with NSTEMI group, the proportion of younger, males, glycemic-lowering drugs, as well as the levels of TC, LDL-C in STEMI group increased significantly, while the proportion of hypertension, IFG/IGT/DM, hyperlipidemia and Hb1Ac level decreased significantly. STEMI group showed a significant increase in IL-2 and IL-6 levels (p < 0.05).

Conclusions: The levels of lipids, Hb1Ac, IL-2 and IL-6 were varying in patients with different stages of coronary heart diseases.The data would contribute to a deeper understanding of the roles of lipids, glucose, and inflammation in the occurrence and development of CAD.

Keywords: Coronary artery disease; Dysglycaemia; Dyslipidemia; Inflammation.