Expression of JAK/STAT signalling in bullous pemphigoid

Laxmi Iyengar; Patrick Hosking; Joel Dowsett; John Su

doi:10.1111/ajd.14389

Expression of JAK/STAT signalling in bullous pemphigoid

Australas J Dermatol. 2024 Nov 21. doi: 10.1111/ajd.14389. Online ahead of print.

Authors

Laxmi Iyengar¹, Patrick Hosking², Joel Dowsett^{2

3}, John Su^{1

3

4}

Affiliations

¹ Department of Dermatology, Eastern Health, Monash University, Melbourne, Victoria, Australia.
² Anatomical Pathology Department, Eastern Health, Melbourne, Victoria, Australia.
³ Department of Dermatology, Austin Health, Melbourne, Victoria, Australia.
⁴ Population Health, MCRI, University of Melbourne, Melbourne, Victoria, Australia.

PMID: 39570002
DOI: 10.1111/ajd.14389

Abstract

In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.

Keywords: JAK signalling; bullous pemphigoid; phosphorylated STAT.