Color distortion often occurs during transmission and reproduction processes, and existing spectral prediction methods have the disadvantage of low prediction accuracy in halftone reproduction. Addressing this issue, this paper establishes a halftone dataset composed of four-color inks (CMYK) mixtures. Based on this, the transformer network is introduced to model and characterize the spectral features of mixed inks, and a forward color formulation prediction model and a reverse spectral prediction model combining halftone reproduction with spectral sequences are proposed, namely the spectrum-color transformer (SC-Former). Color reproduction quality assessment experiments are conducted using the dataset established in this paper and the international standard Ugra/Fogra Media Wedge V3.0 test set. The experimental results show that the SC-Former model outperforms traditional physical models and data-driven prediction models in terms of color reproduction effects and spectral prediction accuracy. This research contributes to the development of high-fidelity color reproduction techniques.