Abstract
In this issue of Molecular Cell, Longo et al.1 reveal that AMPK, a regulatory kinase activated by metabolic stress, inhibits NIX/BNIP3-dependent mitophagy to preserve mitochondrial quantity and activates PINK1/Parkin-dependent mitophagy to ensure mitochondrial quality.
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MeSH terms
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AMP-Activated Protein Kinases* / genetics
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AMP-Activated Protein Kinases* / metabolism
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Animals
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Mitochondria* / enzymology
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Mitochondria* / metabolism
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism
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Mitophagy*
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Protein Kinases* / genetics
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Protein Kinases* / metabolism
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Signal Transduction
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism
Substances
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AMP-Activated Protein Kinases
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Protein Kinases
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PTEN-induced putative kinase
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Ubiquitin-Protein Ligases
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parkin protein
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Mitochondrial Proteins
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Membrane Proteins