Unraveling the tumor-initiating cells in hepatocellular carcinoma

Yu Man Tsui; Daniel Wai-Hung Ho; Irene Oi-Lin Ng

doi:10.1016/j.ccell.2024.10.018

Unraveling the tumor-initiating cells in hepatocellular carcinoma

Cancer Cell. 2024 Nov 13:S1535-6108(24)00406-9. doi: 10.1016/j.ccell.2024.10.018. Online ahead of print.

Authors

Yu Man Tsui¹, Daniel Wai-Hung Ho¹, Irene Oi-Lin Ng²

Affiliations

¹ Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
² Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong. Electronic address: iolng@hku.hk.

PMID: 39577423
DOI: 10.1016/j.ccell.2024.10.018

Abstract

Aggressive features of hepatocellular carcinoma (HCC) are highly related to liver tumor-initiating cells (TICs), which are heterogeneous and plastic. In this issue of Cancer Cell, Yang et al. reveal the ability of CD49f-high TICs in shaping the tumor immunosuppressive microenvironment in HCC.