The Survival, Mechanisms of Failure, and Function After Total Humeral Replacement in Patients with Primary Sarcomas

Zhuoyu Li; Zhiping Deng; Yongkun Yang; Qing Zhang; Xiaohui Niu; Weifeng Liu

doi:10.1016/j.jse.2024.09.030

The Survival, Mechanisms of Failure, and Function After Total Humeral Replacement in Patients with Primary Sarcomas

J Shoulder Elbow Surg. 2024 Nov 21:S1058-2746(24)00847-4. doi: 10.1016/j.jse.2024.09.030. Online ahead of print.

Authors

Zhuoyu Li¹, Zhiping Deng¹, Yongkun Yang¹, Qing Zhang¹, Xiaohui Niu¹, Weifeng Liu²

Affiliations

¹ Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital,Capital Medical University, Beijing 100035,China; National Center for Orthopedics,Beijing 100035,China; Beijing Research Institute of Traumatology and Orthopaedics, Beijing, 100035, China.
² Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital,Capital Medical University, Beijing 100035,China; National Center for Orthopedics,Beijing 100035,China; Beijing Research Institute of Traumatology and Orthopaedics, Beijing, 100035, China. Electronic address: liuweifengjst@163.com.

PMID: 39579857
DOI: 10.1016/j.jse.2024.09.030

Abstract

Background: Total humeral replacement (THR) is one of the few options for reconstruction when the humerus is extensively involved or with skip lesions. However, there are few studies focusing on the long-term outcomes of THR for primary sarcomas, and the function and endoprosthesis survival remains uncertain.

Questions/purposes: The purposes of this study were to answer the following questions: 1) What are the oncological and functional outcomes of total humeral replacement? 2) What are the overall survival and revision-free survival rates of total humeral replacement? 3) What are the failure mechanisms of total humeral replacement?

Methods: A retrospective cohort study was conducted on 34 patients (22 males, 12 females) between January 1997 and December 2021. The average age was 30.1 ± 20.1 years (7 to 72) and the pathological type included osteosarcoma (24), chondrosarcoma (6), Ewing's sarcoma (2) and undifferentiated pleomorphic sarcoma (UPS, 2). The oncological outcomes included local recurrence, metastasis, and overall survival. The functional outcomes were assessed by the Musculoskeletal Tumor Society Score (MSTS-93), the Toronto Extremity Salvage Score (TESS) , the American Shoulder and Elbow Surgeons (ASES) score and the range of motion (ROM) of the shoulder. All modes of failure were recorded in the follow-up. The significance level was adjusted to 0.025 after Bonferroni correction.

Results: The mean follow-up of all patients was 78.5 ± 72.6 months (range, 9 to 292 months) and 103 ± 71.6 months (range, 32 to 292 months) in all survivors. Fourteen patients (41.7%) died in the last follow-up. The 5-year, 10-year, and 15-year overall survival rate of the endoprosthesis was 94% (95% CI 66.6%-99.1%). The average MSTS-93 score was 78% (range, 53% to 86%), the average TESS was 80% (60% to 90%) and the average ASES was 79% (63% to 93%), respectively. The most common failure mechanisms were tumor progression (type 5, 17.6%, 6/34), followed by soft tissue failure (type 1, 14.7%, 5/34), and structural failure (type 3, 2.9%, 1/34).

Conclusions: THR is a long-term reconstructive option for patients with massive tumors requiring complete resection of the humerus. The most common failure mechanisms were tumor progression (type 5) and soft tissue failure (type 1). Overall functional outcomes were acceptable with good hand and elbow function, but shoulder function was limited.

Keywords: Total humeral replacement; endoprosthesis reconstruction; function; mechanical failures; primary sarcomas; survival.