Fabrication of the multifunctional Pd modified NiCuFe Prussian blue analogue nanoplatform and its sensitive colorimetric detection of L-cysteine

Abstract

It is essential to establish a simple, effective and sensitive platform for L-Cysteine (L-Cys) detection because the level of L-Cys is related to many diseases in the human body. Herein, we successfully fabricated polyaniline bridging NiCuFe Prussian blue analogue@palladium (NiCuFe@Pd) nanocomposite with integration of photothermal conversion performance and catalytic performance. And, various spectroscopic and microscopic techniques were adopted to prove the formation of the nanocomposite. 4-nitrothiophenol and 3,3',5,5'-tetramethylbenzidine (TMB) were employed to prove the catalytic activity of the nanocomposite. Due to the catalytic activity, the nanocomposite was used as a nanoplatform for colorimetric detection of L-Cys, which showed high sensitivity with a detection limit as low as 0.027 μM. In addition, the excellent photothermal conversion performance makes it a potential candidate for photothermal therapy for various diseases. This study may be beneficial to promote the construction of novel nanostructures and their medical application.

Keywords: Catalytic; Colorimetric detection; Photothermal.