Tranexamic Acid is Associated With Reduced Blood Loss and Transfusion Requirement in Pediatric Midface Reconstruction

Artur Manasyan; Idean Roohani; Erin Wolfe; Marvee Turk; Mark M Urata; Jeffrey A Hammoudeh

doi:10.1016/j.joms.2024.10.021

Tranexamic Acid is Associated With Reduced Blood Loss and Transfusion Requirement in Pediatric Midface Reconstruction

J Oral Maxillofac Surg. 2024 Nov 9:S0278-2391(24)00917-0. doi: 10.1016/j.joms.2024.10.021. Online ahead of print.

Authors

Artur Manasyan¹, Idean Roohani¹, Erin Wolfe², Marvee Turk², Mark M Urata³, Jeffrey A Hammoudeh⁴

Affiliations

¹ Research Assistant, Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA; Research Assistant, Keck School of Medicine, University of Southern California, Los Angeles, CA.
² Research Physician, Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA; Research Physician, Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, CA.
³ Chief, Attending Surgeon, Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA; Chief, Attending Surgeon, Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, CA.
⁴ Director, Jaw Deformities Care Program, Attending Surgeon, Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA; Director, Jaw Deformities Care Program, Attending Surgeon, Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, CA. Electronic address: Jhammoudeh@chla.usc.edu.

PMID: 39581566
DOI: 10.1016/j.joms.2024.10.021

Abstract

Background: Midface reconstruction poses challenges due to significant blood loss and difficulty in achieving intraoperative hemostasis, often necessitating blood transfusions. Various agents, most notably tranexamic acid (TXA), have been utilized intraoperatively to mitigate this risk of bleeding and transfusion-related complications.

Purpose: The study purpose was to measure the association of TXA with blood loss and transfusion requirements during craniofacial procedures involving the midface.

Study design, setting, sample: This project was designed as a retrospective cohort study. Patients who underwent midface reconstruction at Children's Hospital Los Angeles between 2010 and 2023 were included, and a retrospective chart review was conducted.

Independent variable: The independent variable was weight-adjusted TXA exposure divided into 2 groups: subjects who received TXA preoperatively and intraoperatively and those that did not.

Main outcome variables: The main outcome variables were weight-adjusted intraoperative blood loss and transfusion requirements. Secondary outcomes included intraoperative and postoperative complications and length of stay.

Covariates: Demographic covariates included age at surgery, sex, weight, and syndromic status. Operative covariates covered the type of surgical approach and main procedure performed. Perioperative covariates included anesthesia time and operative time.

Analyses: Parametric and nonparametric variables were analyzed using independent t-test and Wilcoxon rank-sum test, respectively. χ² analysis was used to analyze categorical variables, and multivariable linear regressions were performed. A P value of less than .05 was considered statistically significant.

Results: A total of 80 patients underwent midface reconstruction surgery, 37 (46.3%) of whom received TXA and 43(53.7%) did not. The mean age at surgery was 8.7 ± 3.8 years in the TXA cohort and 11.6 ± 5.1 years in the non-TXA cohort (P = .02). Multivariable regression analysis further demonstrated a statistically significant association between the administration of TXA and both reduced blood loss (coefficient -0.14 [95% CI -0.20 to -0.07], P < .01) as well as reduced transfusion requirement (coefficient -0.14 [95% CI -0.19 to -0.08], P < .01). There was no increased risk of complications, such as thromboembolic events or seizures, in patients who were administered TXA (P = .14).

Conclusion and relevance: TXA is likely a valuable adjunct for improving intraoperative and postoperative outcomes of craniofacial procedures involving the midface.