Comparative Evaluation of Clinical-MRI, Radiomics, and Integrated Nomogram Models for Preoperative Prediction of Placenta Accreta Spectrum

Zhiwei Wang; Xinyao Jiao; Weiwu Liu; Han Song; Jiapeng Li; Jing Hu; Yuanbo Huang; Yang Liu; Sa Huang

doi:10.1016/j.acra.2024.10.021

Comparative Evaluation of Clinical-MRI, Radiomics, and Integrated Nomogram Models for Preoperative Prediction of Placenta Accreta Spectrum

Acad Radiol. 2024 Nov 23:S1076-6332(24)00782-7. doi: 10.1016/j.acra.2024.10.021. Online ahead of print.

Authors

Zhiwei Wang¹, Xinyao Jiao¹, Weiwu Liu¹, Han Song¹, Jiapeng Li¹, Jing Hu², Yuanbo Huang¹, Yang Liu³, Sa Huang⁴

Affiliations

¹ Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, PR China (Z.W., X.J., W.L., H.S., J.L., Y.H., S.H.).
² Changchun University of Science and Technology, Changchun 130022, Jilin, China (J.H.).
³ Changchun University of Chinese Medicine, Changchun 130117, Jilin, China (Y.L.).
⁴ Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, PR China (Z.W., X.J., W.L., H.S., J.L., Y.H., S.H.). Electronic address: huangsa@jlu.edu.cn.

PMID: 39581784
DOI: 10.1016/j.acra.2024.10.021

Abstract

Rationale and objectives: The escalating incidence of placental accreta spectrum (PAS), a pregnancy complication, underscores the need for accurate prenatal diagnosis to guide optimal management strategies. This study aims to develop, validate, and compare various prenatal PAS prediction models integrating clinical data, MRI signs, and radiomics signatures.

Materials and methods: A cohort comprising 111 patients (72 with PAS and 39 without, denoted as N-PAS) served as the training set, while another 47 patients (33 PAS and 14 N-PAS) constituted the validation set. Clinical features and MRI signs were subjected to univariate and multivariate analyses to construct the Clinical-MRI model. Radiomic features were extracted from MRI images and refined through the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm, thereby establishing the Radiomics model. An optimal set of radiomic features was utilized to derive the Radscore, which was then integrated with clinical features and MRI signs to formulate the Nomogram model. The performance of these models was comprehensively evaluated and compared.

Results: In the validation set evaluation, the Nomogram model, which integrated Radscore, a pivotal clinical indicator, and two MRI signs, demonstrated superior performance. With an area under the curve (AUC) of 0.861 (95% CI: 0.745, 0.978), this model significantly outperformed both the clinical-MRI model (AUC = 0.796, 95% CI: 0.649, 0.943) and the radiomics model (AUC = 0.704, 95% CI: 0.531, 0.877). Specifically, the Nomogram model achieved a high sensitivity of 81.8% and a specificity of 78.6% in the prenatal diagnosis of placenta accreta spectrum (PAS), thereby offering clinicians a precise and efficient diagnostic aid.

Conclusion: The radiomics-derived Radscore serves as an independent predictor for prenatal PAS. Combining Radscore with clinical features and MRI signs into a Nomogram model provides a non-invasive tool with high sensitivity or specificity for PAS diagnosis, enhancing prenatal assessment and management.

Keywords: Magnetic resonance imaging; Nomogram; Placenta accreta spectrum; Radiomics.