Real-world therapy and persistence of patients with neovascular age-related macular degeneration and diabetic retinopathy or diabetic macular edema: a German claims data analysis

Julia Krieger; Oliver Cox; Jan-Paul Flacke; Lena Beilschmidt; Sabrina Mueller; Ulf Maywald; Michael Janusz Koss

doi:10.1007/s00417-024-06690-9

Real-world therapy and persistence of patients with neovascular age-related macular degeneration and diabetic retinopathy or diabetic macular edema: a German claims data analysis

Graefes Arch Clin Exp Ophthalmol. 2024 Nov 25. doi: 10.1007/s00417-024-06690-9. Online ahead of print.

Authors

Julia Krieger¹, Oliver Cox², Jan-Paul Flacke³, Lena Beilschmidt³, Sabrina Mueller⁴, Ulf Maywald⁵, Michael Janusz Koss⁶

Affiliations

¹ Cytel Inc., Potsdamer Straße 58, 10785, Berlin, Germany.
² F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland. oliver.cox@roche.com.
³ Roche Pharma AG, Emil-Barell-Straße 1, 79639, Grenzach-Wyhlen, Germany.
⁴ IPAM E.V., Alter Holzhafen 19, 23966, Wismar, Germany.
⁵ Payers GmbH, Heilwigstraße 34, 20249, Hamburg, Germany.
⁶ Eye Center Nymphenburger Höfe, Augenklinik Herzog Carl Theodor, Nymphenburger Str. 4, 80335, Munich, Germany.

PMID: 39586847
DOI: 10.1007/s00417-024-06690-9

Abstract

Purpose: Vascular endothelial growth factor (VEGF) inhibition is the current and high-volume standard-of-care for patients with neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR) with diabetic macular edema (DME). This study assessed the impact of non-persistence in anti-VEGF treatment using claims data from two German states.

Methods: This study identified adults with nAMD or DR/DME and incident anti-VEGF treatment (= index) in January 2015-June 2019 using the German AOK PLUS claims database (January 2014-June 2021, ~ 3.5 million insured). Baseline characteristics were observed within 12 months before index. Patient follow-up lasted ≥ 24 months or until death. Non-persistence (gap of ≥ 180 days) was calculated using Kaplan-Meier estimation. Cox regression identified variables linked to non- persistence. The study analysed reimbursed anti-VEGF treatments, thus excluding off-label use of bevacizumab.

Results: 5,498 patients diagnosed with nAMD (mean age, 80.09 years; male, 37.50%; mean Charlson Comorbidity Index [CCI] score, 3.07) and 484 patients with DR/DME (mean age, 67.14; male, 58.88%; mean CCI score, 4.54) were identified. Non-persistence to anti-VEGF treatment within 12 months after index occurred in 51.38% of nAMD patients and 62.60% of DR/DME patients, with mean times to first gap of 11.28 and 8.98 months, respectively. Cox regression revealed factors associated with non-persistence, including higher age, female gender, higher care needs, longer AMD history, and the use of ranibizumab.

Conclusion: Epidemiologic and ophthalmologic factors associated with anti-VEGF non-persistence were successfully identified in the first year of therapy. The analyzed dataset can potentially be enriched with additional health insurance database sets under the used criteria to gain more understanding of anti-VEGF non-persistence.

Keywords: Adherence; Administrative data; Anti-vascular endothelial growth factor; Diabetic retinopathy; Neovascular age-related macular degeneration; Persistence.