Perioperative severity of acute appendicitis during the confinement related to SARS COVID-19: a retrospective comparative cohort

Elias Bouziane; Manuela Perez; Laurent Brunaud; Amandine Luc; Cédric Baumann; Claire Nomine-Criqui

doi:10.1007/s00464-024-11414-5

Perioperative severity of acute appendicitis during the confinement related to SARS COVID-19: a retrospective comparative cohort

Surg Endosc. 2024 Nov 25. doi: 10.1007/s00464-024-11414-5. Online ahead of print.

Authors

Elias Bouziane¹, Manuela Perez², Laurent Brunaud², Amandine Luc², Cédric Baumann², Claire Nomine-Criqui²

Affiliations

¹ Université de Lorraine Faculté de Médecine: Universite de Lorraine Faculte de Medecine Maieutique et Metiers de la Sante a Nancy, Nancy, Meurthe et Moselle, France. e.bouziane@chru-nancy.fr.
² Université de Lorraine Faculté de Médecine: Universite de Lorraine Faculte de Medecine Maieutique et Metiers de la Sante a Nancy, Nancy, Meurthe et Moselle, France.

PMID: 39586880
DOI: 10.1007/s00464-024-11414-5

Abstract

Objective: To evaluate the perioperative severity of acute appendicitis during the COVID-19 pandemic compared to the same periods in 2018 and 2019 in the Nancy-Metz region, France. Acute appendicitis is a common surgical emergency that can lead to severe complications if not treated promptly. The COVID-19 pandemic and subsequent lockdowns resulted in reduced hospital visits, potentially delaying treatment for appendicitis and increasing perioperative severity.

Methods: This retrospective, bicentric cohort study included 634 adult patients who underwent emergency appendectomy at the Nancy University Hospital and Metz Regional Hospital. The study compared patients from the pandemic period (March 17, 2020, to December 14, 2020) with those from the same periods in 2018 and 2019. The primary outcome was perioperative severity, defined by a Gomes score ≥ 3 and/or a Clavien-Dindo classification ≥ 3. Secondary outcomes included time to treatment, severity of biological inflammatory syndrome, postoperative complications, and hospitalization metrics. Logistic regression analyses were performed with adjustments for ASA scores.

Results: The study included 194 patients from the COVID-19 cohort and 440 from the non-COVID cohort. The perioperative severity was higher during the COVID period (33.5% vs. 25.9%), though this difference was not statistically significant (p = 0.0845). Secondary outcomes such as time to treatment, severity of the inflammatory syndrome, and postoperative complications did not show significant differences between cohorts. However, the duration of postoperative antibiotic therapy was longer during the COVID period (6 days vs. 5 days, p = 0.0410).

Conclusion: The COVID-19 pandemic led to a non-significant increase in perioperative severity of acute appendicitis. Despite the challenges posed by the pandemic, the French healthcare system maintained effective management of surgical emergencies, with no significant increase in postoperative complications. Further research is required to explore the broader impact of the pandemic on the management of appendicitis.

Keywords: Appendectomy; Appenditis; COVID; SARS-CoV-2.