Introduction: Diagnosing oral cancer is crucial in healthcare, with technological advancements enhancing early detection and outcomes. This review examines the impact of handheld AI-based tools, focusing on Convolutional Neural Networks (CNNs) and their advanced architectures in oral cancer diagnosis.
Methods: A comprehensive search across PubMed, Scopus, Google Scholar, and Web of Science identified papers on deep learning (DL) in oral cancer diagnosis using digital images. The review, registered with PROSPERO, employed PRISMA and QUADAS-2 for search and risk assessment, with data analyzed through bubble and bar charts.
Results: Twenty-five papers were reviewed, highlighting classification, segmentation, and object detection as key areas. Despite challenges like limited annotated datasets and data imbalance, models such as DenseNet121, VGG19, and EfficientNet-B0 excelled in binary classification, while EfficientNet-B4, Inception-V4, and Faster R-CNN were effective for multiclass classification and object detection. Models achieved up to 100% precision, 99% specificity, and 97.5% accuracy, showcasing AI's potential to improve diagnostic accuracy. Combining datasets and leveraging transfer learning enhances detection, particularly in resource-limited settings.
Conclusion: Handheld AI tools are transforming oral cancer diagnosis, with ethical considerations guiding their integration into healthcare systems. DL offers explainability, builds trust in AI-driven diagnoses, and facilitates telemedicine integration.
Keywords: Oral cancer; artificial intelligence (AI); convolutional neural network (CNN); deep learning; smartphone device.