A Mendelian randomization study finds no evidence for causal effects of C-reactive protein (CRP) on chronic pain conditions

Pradeep Suri; Yakov A Tsepilov; Elizaveta E Elgaeva; Frances M K Williams; Maxim B Freidin; Ian B Stanaway

doi:10.1093/pm/pnae122

A Mendelian randomization study finds no evidence for causal effects of C-reactive protein (CRP) on chronic pain conditions

Pain Med. 2024 Nov 26:pnae122. doi: 10.1093/pm/pnae122. Online ahead of print.

Authors

Pradeep Suri^{1

2

3

4}, Yakov A Tsepilov^{5

6}, Elizaveta E Elgaeva^{6

7}, Frances M K Williams⁸, Maxim B Freidin⁸, Ian B Stanaway⁹

Affiliations

¹ Division of Rehabilitation Care Services, VA Puget Sound Health Care System, USA.
² Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, USA.
³ Department of Rehabilitation Medicine, University of Washington, Seattle, USA.
⁴ Clinical Learning, Evidence, and Research (CLEAR) Center, University of Washington, Seattle, USA.
⁵ Wellcome Sanger Institute, Cambridge, UK.
⁶ Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.
⁷ Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia.
⁸ Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.
⁹ Department of Nephrology, University of Washington, Seattle, USA.

PMID: 39589921
DOI: 10.1093/pm/pnae122

Abstract

This two-sample Mendelian randomization study examined causal associations of C-reactive protein (CRP) with spinal pain, the extent of multisite chronic pain, and chronic widespread musculoskeletal pain. No causal associations were found between CRP and these pain conditions.