Genome-Wide Identification of the ClpB Gene Family in Tomato and Expression Analysis Under Heat Stress

Int J Mol Sci. 2024 Nov 17;25(22):12325. doi: 10.3390/ijms252212325.

Abstract

Tomato is a widely grown horticultural crop, and its growth process is often affected by high temperatures. Caseinolytic Protease B (ClpB), a homologous protein to heat shock protein 101 (HSP101), plays a vital role in plant heat adaptation and development. In this study, we identified six SlClpB genes in tomatoes, distributed across four chromosomes. Collinearity analysis revealed that the gene pairs SlClpB-2 and SlClpB-3A, as well as SlClpB-3C and SlClpB-12, resulted from segmental duplication events. Phylogenetic and motif analyses showed that ClpB proteins possess highly conserved domains across different species. We used RNA-seq data to analyze the expression patterns of the ClpB family. Among them, SlClpB-3A and SlClpB-12 exhibited increased expression in multiple tissues under heat stress. Specifically, SlClpB-2, SlClpB-3A, and SlClpB-3C were highly expressed in the fruit orange stage and in flower buds under heat treatment, while in seedlings, SlClpB-2 and SlClpB-3A exhibited heat-induced expression. Real-time quantitative fluorescent PCR (qRT-PCR) results showed that the expression of SlClpB-2 and SlClpB-3A was significantly increased under heat stress in the leaves and buds of Ailsa Craig, Micro-Tom, and M82. Overall, our findings provide valuable insights into the regulatory mechanisms of SlClpB genes in response to heat stress.

Keywords: AAA+; Caseinolytic Protease B; Solanum lycopersicum; expression pattern; high temperature.

MeSH terms

  • Chromosomes, Plant / genetics
  • Endopeptidase Clp / genetics
  • Endopeptidase Clp / metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant*
  • Genome, Plant
  • Heat-Shock Response* / genetics
  • Multigene Family*
  • Phylogeny*
  • Plant Proteins* / genetics
  • Plant Proteins* / metabolism
  • Solanum lycopersicum* / genetics
  • Solanum lycopersicum* / metabolism

Substances

  • Plant Proteins
  • Endopeptidase Clp