Insecticidal and Repellent Activity of Piper crassinervium Essential Oil and Its Pure Compounds Against Imported Fire Ants (Hymenoptera: Formicidae)

Molecules. 2024 Nov 18;29(22):5430. doi: 10.3390/molecules29225430.

Abstract

Piper crassinervium Kunth (Piperaceae) essential oil (EO) was evaluated for its toxicity and repellency against red imported fire ants (RIFA), Solenopsis invicta Buren, and a hybrid (HIFA) of red (S. invicta) and black (S. richteri Forel) imported fire ants. Through bioactivity-guided fractionation, two major components, elemicin and myristicin, were isolated from the EO. Removal of treated sand in a digging bioassay was used as the criterion for repellency. The EO showed significantly higher repellency at concentrations of 7.8 µg/g against RIFA and HIFA workers, as compared to the DEET (N,N-diethyl-meta-toluamide) or ethanol control. Elemicin exhibited repellency at 3.9 and 7.8 µg/g against RIFA and HIFA workers, respectively, whereas myristicin was active at 7.8 µg/g against both species. DEET failed at 31.25 µg/g against RIFA and 15.6 µg/g against HIFA. The EO showed LC50 values of 97.9 and 73.7 µg/g against RIFA and HIFA workers, respectively. Myristicin was more toxic against RIFA and HIFA with LC50 values of 54.3 and 35.3 µg/g, respectively. Elemicin showed 20-40% mortality at the highest screening dose of 125 µg/g. Fipronil exhibited the highest toxicity against RIFA and HIFA, with LC50 of 0.43 and 0.51 µg/g, respectively. Different formulations of these natural products should be evaluated to explore their use potential under natural field conditions.

Keywords: Piper crassinervium; digging behavior; essential oil; imported fire ants; repellency; toxicity.

MeSH terms

  • Allyl Compounds
  • Allylbenzene Derivatives
  • Animals
  • Ants*
  • Dioxolanes / chemistry
  • Dioxolanes / pharmacology
  • Dioxoles
  • Fire Ants
  • Insect Repellents* / chemistry
  • Insect Repellents* / pharmacology
  • Insecticides* / chemistry
  • Insecticides* / pharmacology
  • Oils, Volatile* / chemistry
  • Oils, Volatile* / pharmacology
  • Piper* / chemistry
  • Pyrogallol / analogs & derivatives
  • Pyrogallol / chemistry
  • Pyrogallol / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Oils, Volatile
  • Insecticides
  • Insect Repellents
  • myristicin
  • Dioxolanes
  • Sesquiterpenes
  • 5-allyl 6,7-dimethoxy 1,3-benzodioxole
  • Pyrogallol
  • Allylbenzene Derivatives
  • Allyl Compounds
  • Dioxoles