Case report: A case of blood culture-negative Bartonella quintana endocarditis: blood mNGS is an efficient method for early diagnosis

Front Med (Lausanne). 2024 Nov 11:11:1449637. doi: 10.3389/fmed.2024.1449637. eCollection 2024.

Abstract

Bartonella quintana is one of the main causes of blood culture-negative endocarditis, and routine blood culture and serological methods are difficult to achieve early diagnosis. We report a case of blood culture-negative Bartonella quintana endocarditis from southwestern Chongqing. The patient was a 67-year-old male scavenger who presented with heart failure without fever as the main clinical manifestation upon admission. He stated having had contact with stray cats in the past 2 months. The combination of clinical symptoms, echocardiography, and blood mNGS testing confirmed the infection of Bartonella quintana.

Keywords: Bartonella quintana; blood culture-negative; cardiac failure; infective endocarditis; metagenomic nextgeneration sequencing.

Publication types

  • Case Reports

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The study was supported by the First batch of key Disciplines on Public Health in Chongqing (YWBF2022072).