Pyrimidine Nucleosides, Benzoic Acid Derivative and Bipyridine from the Marine-Derived Streptomyces sp. DS52

Mengde Xia; Jiebin Fang; Yun Huang; Shuang Chen; Zhongjun Ma

doi:10.1002/cbdv.202402322

Pyrimidine Nucleosides, Benzoic Acid Derivative and Bipyridine from the Marine-Derived Streptomyces sp. DS52

Chem Biodivers. 2024 Nov 27:e202402322. doi: 10.1002/cbdv.202402322. Online ahead of print.

Authors

Mengde Xia¹, Jiebin Fang², Yun Huang², Shuang Chen², Zhongjun Ma³

Affiliations

¹ Zhejiang University, Zhoushan Campus, Dinghai District Lincheng street, 316021, Zhoushan, CHINA.
² Zhejiang University, Zhoushan Campus, Dinghai District Lincheng street, Zhoushan, CHINA.
³ Zhejiang University, Ocean Department, No.1 Zheda Road, 316021, Zhoushan, CHINA.

PMID: 39601488
DOI: 10.1002/cbdv.202402322

Abstract

Fourteen new compounds were isolated from marine-derived Streptomyces sp. DS52, including twelve pyrimidine nucleosides (1-12), one benzoic acid derivative (13) and one dipyridine derivative (14). Additionally, twenty-eight known compounds (15-42) were identified. The structures of all compounds were elucidated through extensive analysis of NMR spectroscopic and HRESIMS data. ECD calculations were employed to investigate the configurations of compounds 1, 2 and 4-13. Bioactivity evaluations of all of the compounds showed that compounds 6, 7, 9, 11, 15, 33-38, 41, and 42 exhibited cytotoxicity against HCT-116 human colon cancer cell lines and MDA-MB-231 human breast cancer cell lines, with IC50 values ranging from 0.73 ± 0.06 to 17.44 ± 0.53 μM and from 1.11 ± 0.06 to 18.51 ± 3.07 μM, respectively. Notably, compound 41 exhibited significant cytotoxicity against the HCT-116 and MDA-MB-231 human cancer cell lines with IC50 values of 0.73 ± 0.06 and 1.11 ± 0.06 μM, respectively.

Keywords: Amicetin; Separation and Extraction.