Objective: To explore the prognostic value of BRCA1-associated protein 1 (BAP1) expression loss in patients with malignant mesothelioma (MM) . Methods: A total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis. Kaplan-Meier method was used to draw the survival curve, and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate. Results: Among 82 MM patients, 61 (74.4%) were female, aged (57±11) years. BAP1 protein expression was deficient in 39 patients (47.6%). The survival rate was correlated with the loss of BAP1 protein expression and age (χ(2)=5.27, 5.66, P=0.022, 0.017). Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients <57 years of age, female, pleural MM, epithelial MM, and treated with drugs or surgery (P<0.05). Multivariate model results showed that positive expression of BAP1 protein (HR=3.75, 95%CI: 2.23-6.30, P<0.001) and age ≥57 years (HR=1.66, 95% CI: 1.01-2.72, P=0.049) were risk factors for survival in patients with MM. Conclusion: Loss of BAP1 protein expression may be an independent prognostic factor in patients with MM, which is associated with longer survival.
目的： 探索BRCA1相关蛋白1（BRCA1-associated protein 1，BAP1）表达缺失对恶性间皮瘤（malignant mesothelioma，MM）患者的预后价值。 方法： 选取浙江省1998年1月至2017年12月收治的82例MM患者，通过免疫组织化学分析检测BAP1蛋白的表达。用Kaplan-Meier法绘制生存曲线，用多变量Cox比例风险模型分析生存率的影响因素。 结果： 82例MM患者中女性61例（74.4%），年龄（57±11）岁。39例（47.6%）患者存在BAP1蛋白表达缺失。患者生存率与BAP1蛋白表达缺失及其年龄相关（χ(2)=5.27、5.66，P=0.022、0.017）。亚组分析显示，BAP1蛋白表达缺失与年龄<57岁、女性、胸膜MM、上皮型MM、采用药物或手术治疗方法的MM患者预后较好相关（P<0.05）。多变量模型结果显示，BAP1蛋白阳性表达（HR=3.75，95%CI：2.23~6.30，P<0.001）以及年龄≥57岁（HR=1.66，95%CI：1.01~2.72，P=0.049）是MM患者生存的危险因素。 结论： BAP1蛋白表达缺失可能是MM患者的独立预后因素，与患者较长的生存率相关。.
Keywords: Asbestos; BRCA1-associated protein 1, BAP1; Immunohistochemistry; Malignant mesothelioma, MM; Mesothelioma; Prognosis.