Crotonylation modification and its role in diseases

Yi Guo; Junqin Li; Kaiming Zhang

doi:10.3389/fmolb.2024.1492212

Crotonylation modification and its role in diseases

Front Mol Biosci. 2024 Oct 31:11:1492212. doi: 10.3389/fmolb.2024.1492212. eCollection 2024.

Authors

Yi Guo¹, Junqin Li¹, Kaiming Zhang¹

Affiliation

¹ Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Central Hospital of Shanxi Medical University, Taiyuan, China.

Abstract

Protein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades. Crotonylation is conserved and is regulated by a series of enzymes including "writer", "eraser", and "reader". In recent years, crotonylation has received extensive attention due to its breakthrough progress in reproduction, development and pathogenesis of diseases. Here we brief the crotonylation-related enzyme systems, biological functions, and diseases caused by abnormal crotonylation, which provide new ideas for developing disease intervention and treatment regimens.

Keywords: crotonylation; disease; histone; non-histone protein; post-translational modification.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Natural Science Foundation of China (No. 82273539).