A sensitive electrochemical sensor based on CoWO4/multi-walled carbon nanotubes for the selective determination of chlorpromazine hydrochloride

Si Zeng; Peiyao Zhu; Deyu Liu; Yongmei Hu; Qitong Huang; Haiping Huang

doi:10.1039/d4an01298d

A sensitive electrochemical sensor based on CoWO₄/multi-walled carbon nanotubes for the selective determination of chlorpromazine hydrochloride

Analyst. 2024 Nov 28. doi: 10.1039/d4an01298d. Online ahead of print.

Authors

Si Zeng¹, Peiyao Zhu¹, Deyu Liu¹, Yongmei Hu¹, Qitong Huang^{1

2}, Haiping Huang¹

Affiliations

¹ Key Laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation, School of Chemistry and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou, 341000, China. hqt@gmu.edu.cn.
² School of Medical and Information Engineering, The Science Research Center, Gannan Medical University, Ganzhou, China.

PMID: 39606903
DOI: 10.1039/d4an01298d

Abstract

In this work, a novel electrochemical sensor based on cobalt tungstate/multi-walled carbon nanotube (CoWO₄/MWCNT) nanocomposites has been used to detect chlorpromazine hydrochloride (CPZ). The CoWO₄/MWCNT nanocomposite was obtained by solvothermal technology and ultrasonic method and analyzed using different characterization techniques such as scanning electron microscopy (SEM), X-ray diffractometry (XRD), energy-dispersive spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of CoWO₄/MWCNT/GCE was explored using cyclic voltammetry (CV). Electrochemical experiments confirm that CoWO₄/MWCNT/GCE exhibits excellent electrocatalytic activity towards CPZ with good selectivity, reproducibility and stability. The linear dynamic range of CPZ was observed to be 1-2000 μM with a detection limit of 0.33 μM. Moreover, the actual sample was analyzed using lake water with satisfactory results, portraying the sensor as a potential candidate for the detection of CPZ.